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intc

An implementation of the *-INC method to calculate an empirical FDR for non-targeting controls in CRISPR screens

Owned by Noam Teyssier.

13 releases

0.3.6 Oct 7, 2024
0.3.5 Sep 6, 2024
0.3.3 May 22, 2023
0.2.1 May 17, 2023
0.1.4 Feb 2, 2023

#278 in Biology

Download history 9/week @ 2024-07-01 17/week @ 2024-07-15 73/week @ 2024-07-29 22/week @ 2024-08-05 13/week @ 2024-08-12 38/week @ 2024-08-26 351/week @ 2024-09-02 63/week @ 2024-09-09 39/week @ 2024-09-16 15/week @ 2024-09-23 36/week @ 2024-09-30 209/week @ 2024-10-07 14/week @ 2024-10-14

276 downloads per month
Used in crispr_screen

MIT license

45KB
1K SLoC

intc

Including Non-Targeting Controls

This is a library to perform mann-whitney U tests to aggregate sgRNA enrichment p-values at the gene-level and calculate an empirical false discovery rate via bootstrapping of pseudo-genes composed of non-targeting controls.

Dependencies

~10MB
~185K SLoC